No articles match
Guiding Oncology Dose-Escalation Trials2 months ago
Introduction | Example use-case: Dual combination trial with historical information | Setting up the trial design | Drug info | Dose info | Initializing a blrm_trial | Specifying the prior and fitting the model | Summary of prior specification | Summary of posterior | Posterior accuracy of EWOC estimation | Posterior predictive summaries | Updating the model with new data | Data scenarios | Continuation of example: Using concurrent data | References | Session Info
Meta-Analytic-Predictive (MAP) approach for dose-toxicity modelling2 months ago
Introduction | Application background | Historical data | Derivation of MAP priors | Drug A model | Drug B model | Extraction of MAP priors | MCMC samples | Mixture approximation | Combination model with MAP priors for the new study | Robustification | Equivalence of MAP and MAC (advanced) | Appendix: Model specification | Combination BLRM (new study model) | Prior specification | Meta-analytic models for the historical data | Hierarchical model for combined data (MAC) | References | Session Info